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As shown in Scheme 1,9- and 7-substituted tetracycline compounds can be synthesized by treating a tetracycline compound (e.g., doxycycline, 1A), with sulfuric acid and sodium nitrate. Il vantaggio di avere tre dosi disponibili consiste nel fatto che il tuo medico può ridurre o aumentare il trattamento oppure mantenerlo identico in base alla tua risposta individuale.

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